ICSI Research Today is a free monthly online journal that collates and summarizes the latest research about ICSI, including details on infertility, ivf, success rates, treatment, risks.

Ongoing twin pregnancy after rescue intracytoplasmic sperm injection of unfertilized abnormal oocytes.

Esfandiari N, Claessens EA, Burjaq H, Gotlieb L, Casper RF

Toronto Centre for Advanced Reproductive Technology (TCART), Toronto, Canada. nesfand@excite.com

OBJECTIVE: To report a case of an ongoing twin pregnancy resulting from rescue intracytoplasmic sperm injection (ICSI) after failed fertilization of morphologically abnormal oocytes. DESIGN: Case report. SETTING: Tertiary center for assisted reproductive technology (ART). PATIENT(S): A 28-year-old woman with primary infertility due to tubal obstruction. INTERVENTION(S): Rescue ICSI after failed IVF insemination. MAIN OUTCOME MEASURE(S): Clinical pregnancy. RESULT(S): Successful ongoing twin pregnancy. CONCLUSION(S): With failed fertilization of oocytes with abnormal morphology after IVF, early rescue ICSI may increase the fertilization rates and result in an ongoing pregnancy.

Published 1 July 2008 in Fertil Steril, 90(1): 199.e5-7.
Full-text of this article is available online (may require subscription).

Articles on ICSI published 1 July 2008:

Assisted reproductive technology may increase clinical mutation detection in male offspring.   Fertil Steril, 90(1): 92-6.

OBJECTIVE: To investigate the risks of chromosome mutation after ART for couples with comparable genetic backgrounds. DESIGN: Prospective clinical observational study. SETTING: In vitro fertilization center at a tertiary-care, university-affiliated teaching hospital. PATIENT(S): Ninety-seven male children whose fathers have normal spermatogenesis were recruited, including 19 babies conceived through IVF, 18 babies conceived through intracytoplasmic sperm injection (ICSI), and 60 naturally ... [Abstract] [Full-text]

Sperm head's birefringence: a new criterion for sperm selection.   Fertil Steril, 90(1): 104-12.

OBJECTIVE: To investigate the characteristics of birefringence in human sperm heads and apply polarization microscopy for sperm selection at intracytoplasmic sperm injection (ICSI). DESIGN: Prospective randomized study. SETTING: Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy. PATIENT(S): A total of 112 male patients had birefringent sperm selected for ICSI (study group). The clinical outcome was compared with that obtained in 119 couples who ... [Abstract] [Full-text]

The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.   Fertil Steril, 90(1): 60-4.

OBJECTIVE: To investigate the association between the levels of two steroid hormones and eight cytokines in fluids from individual follicles and the fertilization outcome of the oocytes derived from the same follicles. DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): Forty-three women participating in intracytoplasmic sperm injection (ICSI)/ET cycles. INTERVENTION(S): The ovarian stimulation followed the multidose GnRH antagonist protocol. ICSI was performed in mature ... [Abstract] [Full-text]

Evidence of absence or absence of evidence? A reanalysis of the effects of low-dose aspirin in in vitro fertilization.   Fertil Steril, 90(1): 71-6.

OBJECTIVE: To assess the conflicting evidence whether low-dose aspirin is beneficial in IVF and to evaluate the meta-analysis performed by Gelbaya et al. and reported in March 2007 in Human Reproduction Update, in which they found no effects of low-dose aspirin and recommended discontinuing its use in IVF. We present a reanalysis of the effects of low-dose aspirin in IVF and raise methodological questions regarding the analysis by Gelbaya et al. DESIGN: A meta-analysis of prospective randomized ... [Abstract] [Full-text]

Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles.   Fertil Steril, 90(1): 97-103.

OBJECTIVE: To determine whether male age influences embryo development and reproductive potential in assisted reproductive technology cycles. DESIGN: Retrospective cohort analysis. SETTING: Private IVF center. PATIENT(S): One thousand twenty-three male partners participating in anonymous oocyte donation cycles. INTERVENTION(S): Infertile couples undergoing 1,023 anonymous oocyte donation cycles. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): A significant increase in pregnancy loss, ... [Abstract] [Full-text]

Spindle imaging: a marker for embryo development and implantation.   Fertil Steril, 90(1): 194-8.

OBJECTIVE: To examine whether the presence of birefringent spindles in living human oocytes can be used as a predictive factor associated with embryo morphology to allow embryo selection before transfer and its association with IVF outcomes. DESIGN: Prospective study. SETTING: Assisted reproduction center in Brazil. PATIENT(S): One hundred fifty-seven patients undergoing intracytoplasmic sperm injection cycles, resulting in 1,097 metaphase II oocytes. INTERVENTION(S): Meiotic spindles were ... [Abstract] [Full-text]

Articles on ICSI published 20 May 2008:

Sperm DNA fragmentation in subfertile men: the effect on the outcome of intracytoplasmic sperm injection and correlation with sperm variables.   BJU Int, 101(12): 1553-60.

OBJECTIVE: To present the first UK data on sperm DNA fragmentation levels in subfertile men and fertile controls, the correlation with semen variables, and to assess the effect on the outcome of intracytoplasmic sperm injection (ICSI). PATIENTS, SUBJECTS AND METHODS: In all, 56 subfertile men undergoing ICSI (28 with positive and 28 with a negative outcome for paternity) and 10 control fertile semen donors were recruited. The sperm DNA fragmentation index (DFI) was assessed on raw ... [Abstract] [Full-text]

Articles on ICSI published 15 April 2008:

Accuracy of soluble human leukocyte antigen-G for predicting pregnancy among women undergoing infertility treatment: meta-analysis.   Hum Reprod Update, 14(3): 209-18.

BACKGROUND: There have been concerns about validity and accuracy of the measurement of sHLA-G in embryo culture supernatants. In this systematic review, we quantified the diagnostic accuracy of sHLA-G for predicting the ability to achieve clinical pregnancy in women who are undergoing infertility treatment. METHODS: Medline and Embase were searched up to 7 September 2007, for full English and non-English articles concerning cohort studies evaluating sHLA-G in embryo culture for predicting ... [Abstract] [Full-text]

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